Chemotherapy for MS Treatment: What You Need to Know

Chemotherapy for MS Treatment: What You Need to Know

Ins and Outs of Chemotherapy for MS Treatment

If you have multiple sclerosis (MS), you know there are a lot of treatments available for your symptoms. You may also know there are so many treatments available because everyone’s MS responds differently.

For MS that doesn’t respond to conventional treatment, doctors are now finding that chemotherapy may be beneficial. Chemotherapy is a type of treatment regimen that was once reserved for cancer. It is now branching into other areas of disease, as it has proven effective for various other types of illness.

Conventional MS Treatment

Conventional treatment of MS is dependent on the type of MS. However, it is generally aimed at reducing symptoms, reducing disability and prolonging remission. There are a variety of medications available for MS treatment.

Mild flare-ups may not require medications. However, larger scale flare-ups generally require some type of treatment in order to feel better.

The typical treatment for a flare-up is methylprednisolone (Solu-Medrol) or prednisone (Deltasone) given intravenously once daily for three to five days. These medications are steroids that can reduce inflammation, causing the exacerbation to end quicker, thus reducing symptoms.

Plasmapheresis is also an option for an exceptionally severe flare-up, or if the flare-up is not responding to IV steroid treatment. Plasmapheresis is when the plasma is separated from the blood. Plasma from a donor is infused back into the bodies; this plasma does not have the antibodies that the MS sufferer may have that makes them sick.

As you know, MS can cause a lot of different symptoms, such as bladder and bowel problems, depression, vertigo, fatigue, pain, sexual problems, spasticity, tremors and gait difficulties, and the dreaded MS itch.


A variety of medications are available, depending on the symptom present. These medications are not MS-specific medications, but are specific for treatment of that specific symptom.

There are also a variety of medications that may slow the progression of MS. These medications typically work for people who have relapsing forms of MS.

These medications come from a variety of drug classes. They may be injectable (given via a shot), oral, or given through an IV.

If you have a relapsing form of MS, you have probably been prescribed either an interferon beta formulation or glatiramer acetate (GA). However, as many as two-thirds of MS sufferers experienced a relapse during the initial two years of treatment.

If you are one of the 66 percent who suffered a relapse during the initial two years of treatment, research is proving that perhaps a chemotherapeutic medication may be in your best interest.

Chemotherapy for MS

You may hear “chemotherapy” and instinctively think “cancer” — and that can be scary. You may get scared of the side effects, and you may get scared because you know chemotherapy may cure cancer, but it will not cure your MS.

It is true it won’t cure your MS, but it may slow the progression dramatically.

Benefits of Chemotherapy for MS

Chemotherapy is not meant to be the first-line medication for MS treatment. It can be helpful for people who have failed on first-line medications.

Chemotherapy given to MS patients has proven to slow the progression of the disease. It is an immunosuppressive agent and may suppress the activity of MS, so it may help when other medications have not.

Pros and cons should be weighed prior to initiating chemotherapy treatment. Chemotherapy should only be initiated if the benefits outweigh the risks.

Approved Chemotherapy Drugs for MS

Novantrone (mitoxantrone) is the only chemotherapy agent approved by the Food and Drug Administration for treatment for MS.

However, other chemotherapy agents may also be used to treat MS. They would be prescribed off-label but may be used with the same efficacy as Novantrone. Some of these drugs include Imuran (azathioprine), Cytoxan (cyclophosphamide) and Leustatin (cladribine).

Side Effects of Chemotherapy for MS

The scariest thing about giving chemotherapy for MS is side effects. You may already have so many symptoms to manage that adding more to your plate is undesirable.

However, if you decide that in the short-term the side effects are worth it, it is important to know the side effects of chemotherapy medications:

  • Thinning or loss of hair
  • Weakening of the heart (cardiomyopathy)
  • Leukemia
  • Liver inflammation
  • Increased risk of infection, caused by a suppression of bone marrow with a decrease in white blood cell count
  • Nausea and vomiting

What to Expect When Receiving a Chemotherapy Treatment

If bloodwork is required prior to your treatment, make sure you get it as ordered so you do not hold up your treatment.

A chemotherapy treatment can take a few hours. Be comfortable and bring something to occupy yourself, such as a book, magazine or a laptop.

You can expect to be monitored closely by your nurse during your treatment. They will check your vital signs before and after your treatment, at the minimum.

You’ll probably get a “cocktail” of medications. Chemotherapy is often accompanied by an IV steroid such as Solu-Medrol and an anti-nausea medication, such as Zofran or Reglan. You’ll probably also have IV fluids flowing.

As chemotherapy can suppress the immune system and make you more susceptible to infection, after receiving a treatment you’ll want to avoid sick people for about the first two weeks after your treatment.


Every Day Health (Chemotherapy Drug for MS: Fear of Side Effects)

National Multiple Sclerosis Society (Managing Relapses)

National Multiple Sclerosis Society (Medications)

National Center for Biotechnology Information (Chemotherapeutics in the Treatment of Multiple Sclerosis)

WebMD (Multiple Sclerosis and Cytoxan Therapy)

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